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Forbes Business News

Customer captivity is difficult to create with customers who can just click around to find a substitute product or a cheaper price.  The online travel business is a classic example of customers made disloyal through brutal competitive pricing and thousands of ways a traveler can get information and book trips.

Sorry to get TMI on you, but we all spend a lot of time in the bathroom. And many things about that room — the fact that you're alone in there without distractions, the amount of fixed design elements crammed into a small space, the potential for dirt and clutter — give it the potential to look outdated quite quickly. No wonder it's consistently been the most popular home renovation project in this country.

In one of the largest initiatives of its kind, the for-profit hospital chain Hospital Corporation of America (HCA) has embarked on a plan to molecularly profile the tumor of cancer patients, marry the genomic information to clinical data from a patient’s electronic health record, and recommend targeted therapies. In a one-size-fits-all approach, patients who now receive a cancer diagnosis get the standard of treatment, which may or may not work. Those who fail first-line treatments are then subjected to other therapies through trial and error. “We’re seeing the light,” says Howard Burris, chief medical officer of Sarah Cannon, an arm of HCA which runs 75 cancer centers across the country and the U.K., and is heavily involved in cancer drug development. Its facilities treat more than 100,000 newly diagnosed cancer patients annually.  Two years ago, Sarah Cannon profiled the tumor of 1,000 late-stage cancer patients to match them with the appropriate early phase clinical trial, and hopefully boost their outcomes. The results which Sarah Cannon presented at the American Society of Clinical Oncology last year, showed that up to 25% of patients enrolled in a trial based on their mutation.  While promising, the project proved overwhelming in terms of tracking various clinical and genomic data. To profile cancer patients on a grand scale, patient information had to be aggregated and displayed in a way doctors can understand, to enable them to recommend the right therapy or clinical trial. To do so, HCA reached out to Syapse, a venture-backed start-up that counts Intermountain Healthcare, University of California San Francisco, and Stanford University School of Medicine among its customers. It is deploying its software to some 60 oncologists in Nashville, Tenn., HCA’s headquarters, before expanding to other Sarah Cannon outposts in Florida and other states later this year. Through its platform, doctors will be able to measure the impact of a tailored treatment in conjunction with a patient’s history, other treatments, biopsies, side effects, and other relevant clinical information that reside in an electronic health record. “We’re collaborating with them to implement this at scale,” says Jonathan Hirsch, Syapse’s founder.  “The real missing piece is the physician looking at the cancer patient, and determining that the patient needs to be profiled. They might think they don't need it yet, or some don't have the education,” says Burris. Patients who’ve experienced a recurrence, have advanced or a hard to treat cancer will have their tumor profiled. Insurance companies typically don’t reimburse genomic profiling of newly diagnosed patients.   

Make entertaining easy with these ideas for casual get-togethers

Reuters Environment

SAN DIEGO (Reuters) - California sea lions – mainly pups – are turning up stranded and starved on Southern California beaches in record numbers this year, leaving experts worried that this winter may be the worst season ever documented for the marine mammals.

SALMON, Idaho (Reuters) - The U.S. Forest Service adopted a rule on Wednesday that requires managers of the nation’s nearly 200 forests and grasslands to formally designate where snowmobiles can be operated on the 193 million acres of public land the agency oversees.

SEATTLE (Reuters) - In a message to residents who don't take composting seriously, the city of Seattle is placing red tags on the bins of anyone who fails to comply with a new law barring food scraps from being tossed in the garbage, a spokesman said on Wednesday.

OSLO (Reuters) - Billion-dollar investments in basic transport and electricity in developing nations are among the best ways to curb hunger by 2030 since a quarter of all food is now wasted after harvest, according to a report issued on Thursday.

Reuters Science News

SAN FRANCISCO (Reuters) - Charles Townes, who shared the 1964 Nobel Prize in Physics for invention of the laser, a feat that revolutionized science, medicine, telecommunications and entertainment, has died at age 99, the University of California at Berkeley reported.

NEW YORK (Reuters) - When patients with Parkinson's disease received an injection described as an effective drug costing $1,500 per dose, their motor function improved significantly more than when they got one supposedly costing $100, scientists reported on Wednesday.

WASHINGTON (Reuters) - A partial skull retrieved from a cave in northern Israel is shedding light on a pivotal juncture in early human history when our species was trekking out of Africa to populate other parts of the world and encountered our close cousins the Neanderthals.

Orange County, Ca (Reuters) - Welcome to the utility industry's future - or at least that's what Southern California Edison is hoping.

Reuters Internet News

SAN FRANCISCO (Reuters) - Facebook Inc's revenue grew 49 percent in the fourth quarter, as mobile advertising growth helped the world's largest Internet social network beat Wall Street's targets for earnings and sales.

NEW YORK (Reuters) - Time Warner's TWX.N HBO is preparing to sell a standalone service over the Internet for the first time, in one of the most closely watched moves in pay TV history. Yet the road to the launch has been far from an easy one - marked by changes in strategy, deadlines, and the departure of its chief technology officer along with two of his lieutenants.

WASHINGTON (Reuters) - New U.S. "net neutrality" rules are expected to regulate for the first time deals in which content companies such as Netflix Inc pay broadband providers to connect with their networks for smooth downloads, according to people familiar with the plan.

NEW YORK (Reuters) - A New York computer consultant testified on Wednesday about how a heroin addiction led him to become a prolific drug dealer on Silk Road, as prosecutors moved closer to finishing their case against the underground website's alleged operator.

Functional Safety

We are experienced with the standard IEC 61508 from the aerospace industry. Use our expertise in this field for implementation of the ISO 26262 in the automotive sector.


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